鲍晓明
发布人:研究生处  作者:  发布时间:2018-11-01   浏览次数:547

  

姓名

鲍晓明

性别

出生年月

1961.11

籍贯

山东

政治面貌

中国党员

学历、学位

博士

行政职务


专业技术职务

教授

专业

微生物学

导师类别

博导

博导兼职单位

山东大学

电子邮箱

baoxm@qlu.edu.cn;  bxm@sdu.edu.cn

个人简历:

1993.9–1997.7, 山东大学, 微生物学, 理学博士, 导师: 王祖农

1985.9–1988.7, 山东农业大学, 真菌学, 农学硕士, 导师: 姜广政

1979.9–1983.7, 山东大学, 微生物学, 理学学士, 导师: 高东

2018.1-至今, 齐鲁工业大学, 生物工程学院, 教授

2002.11-2017.12, 山东大学, 微生物技术国家重点实验室, 教授

1996.12-2002.11, 山东大学, 微生物技术国家重点实验室, 副教授

1988.9-1996.11, 山东大学, 微生物技术国家重点实验室, 讲师

1983.7-1988.9, 华中农业大学, 土化系, 助教

研究方向: 

  微生物遗传学与分子生物学。主要关注酿酒酵母(Saccharomyces cerevisiae),开展代谢工程、系统生物学、合成生物学的研究。根据代谢途径工程原理,对酿酒酵母代谢途径进行理性设计并辅助非理性研究手段,开展拓宽酒精发酵底物范围酵母代谢工程研究,使酿酒酵母获得利用木糖产生乙醇的能力,拓宽并提高乙醇发酵的底物利用,为实现纤维素水解液全糖发酵乙醇产业化技术奠定了扎实的基础。相关结果始终国际同类研究的前沿水平同步。同时在各类组学研究的基础上,揭示酿酒酵母高效共转化木糖/葡萄糖,及高抗逆性的分子机理。并开展酿酒酵母高效分泌元件与异源蛋白兼容性的规模化研究,开展酿酒酵母糖运输蛋白的研究。研究特色为理论联系实际,在酿酒酵母分子生物学、遗传学的基础与应用技术领域已形成明显研究特色。

主要科研成果:

科研项目

1、承担自然科学基金面上项目:批准号31870063,从三维基因组深度研究酿酒酵母抗性机制及高抗性与高木糖代谢的拮抗性。直接经费59万元。20191月-202112月。(从齐鲁工业大学申请)

2、主持山东省重点研发计划:2017CXGC1105甘薯生物质制备新型食品增味剂关键技术研发及产业化,200万元,20171—201812月。(从合作方山东圣琪公司申请的)参加山东省科技重大专项(新兴产业):2015ZDXX0403B02,秸秆制浆废渣酶解发酵生产燃料乙醇技术,300万元

3、承担国家自然科学基金面上项目:批准号31470219,酿酒酵母高效分泌元件与异源蛋白兼容性的规模化研究,20151月-201812月,85万元。

4、承担山东龙力生物科技股份有限公司山东省秸秆生物炼制技术重点实验室项目:五碳糖和六碳糖共发酵产乙醇和大宗化学品高效工业菌株选育和发酵条件优化,201411日-20151231日,15

5、承担国家能源局子项目:NY20130402,万吨级纤维素乙醇生产关键技术研究及示范,201311日-20151231日,145万元(共860万)

论文:

1、汪城墙,李洪兴,徐丽丽,沈煜,侯进,鲍晓明*,酿酒酵母戊糖转运蛋白及C6/C5共代谢菌株的研究进展。生物工程学报,2018.34(10):1543-1555(第一单位:齐鲁工业大学)

2Tang H, Wang J, Wang S, Shen Y, Petranovic D, Hou J, Bao X*. “Efficient yeast surface-display of novel complex synthetic cellulosomes.” Microbial Cell Factories. 2018, 17:122.

3Wei, S., Liu, Y., Wu, M., Ma, T., Bai, X., Hou, J., Shen, Y., Bao, X.. Disruption of the transcription factors Thi2p and Nrm1p alleviates the post-glucose effect on xylose utilization in Saccharomyces cerevisiae. Biotechnol Biofuels, 2018, 11, 112.

4Chen, X., Yang, X., Shen, Y., Hou, J., Bao, X.*, Screening Phosphorylation Site Mutations in Yeast Acetyl-CoA Carboxylase Using Malonyl-CoA Sensor to Improve Malonyl-CoA-Derived Product. Front Microbiol. 2018, 947. published: 25 January 2018. doi: 10.3389/fmicb.2018.00047

5Liu, Gang, Zhang, Qiang, Li, Hongxing, Qureshi, Abdul Sattar, Zhang, Jian, Bao Xiaoming*, Bao Jie*. Dry biorefining maximizes the potentials of simultaneous saccharification and co-fermentation for cellulosic ethanol production. Biotechnology and Bioengineering. Biotechnol Bioeng. 2018 Jan;115(1):60-69.

6Chengqiang Wang1, Yanwei Li1, Chenxi Qiu1, Shihao Wang, Jinjin Ma, Yu Shen, Qingzhu Zhang, Binghai Du, Yanqin Ding*, Xiaoming Bao*. Identification of important amino acids in Gal2p for improving the L-arabinose transport and metabolism in Saccharomyces cerevisiae. Frontiers in Microbiology, 2017, 8: 1391.

7Chengqiang Wang1, Jianzhi Zhang1, Chenxi Qiu, Shihao Wang, Yu Shen, Binghai Du, Yanqin Ding*, Xiaoming Bao*. Coutilization of D-Glucose, D-Xylose, and L-Arabinose in Saccharomyces cerevisiae by Coexpressing the Metabolic Pathways and Evolutionary Engineering. BioMed Research International, 2017, 2017: 5318232.

8Wang, X. N. and X. M. Bao. The absence of the transcription factor Yrr1p, identified from comparative genome profiling, increased vanillin tolerance due to enhancements of ABC transporters expressing, rRNA processing and ribosome biogenesis in Saccharomyces cerevisiae Frontiers in microbiology 2017, 8: 367.  DOI: 10.3389/fmicb.2017.00367.  

9Xiaoxu Chen, Xiaoyu Yang, Yu Shen, Jin Hou*, and Xiaoming Bao, Increasing Malonyl-CoA Derived Product through Controlling the Transcription Regulators of Phospholipid Synthesis in Saccharomyces cerevisiae, ACS Synth. Biol. 2017, May 19;6(5):905-912 DOI: 10.1021/acssynbio.6b00346

10Hongting Tang, Meihui Song, Yao He, Jiajing Wang, Shenghuan Wang, Yu Shen, Jin Hou*and Xiaoming Bao1,2 Engineering vesicle trafcking improves the extracellular activity and surface display effciency of cellulases in Saccharomyces cerevisiae. Biotechnology for Biofuels. (2017) 10:53 DOI 10.1186/s13068-017-0738-8

11Zhao J, Li C, Zhang Y, Shen Y, Hou J, Bao X*. Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae. Microb Cell Fact. 2017 Jan 31;16(1):17. doi: 10.1186/s12934-017-0641-9.

12Chen, L., Wang, M., Hou, J., Fu, J., Shen, Y., Liu, F., & Bao*, X., HAL2 overexpression induces iron acquisition in bdf1Δ cells and enhances their salt resistance. Current Genetics, 2016, 63(2), 229-239, DOI 10.1007/s00294-016 -0628-9.

13Wang X, Liang Z, Hou J, Bao X*, Shen Y: Identification and functional evaluation of the reductases and dehydrogenases from Saccharomyces cerevisiae involved in vanillin resistance. BMC Biotechnology 2016, 16(1):1-9.

14Jianzhi Zhao#, Xiaoming Bao#, Chen Li, Yu Shen, Jin Hou*. Improving monoterpene geraniol production through geranyl diphosphate synthesis regulation in Saccharomyces cerevisiae, Appl Microbiol Biotechnol. 2016 May;100(10): 4561-71, DOI 10.1007/s00253-016-7375-1

15Hongting Tang, Shenghuan Wang, Jiajing Wang, Meihui Song, Mengyang Xu, Mengying Zhang, Yu Shen, Jin Hou & Xiaoming Bao, N-hypermannose glycosylation disruption enhances recombinant protein production by regulating secretory pathway and cell wall integrity in Saccharomyces cerevisiae. Scientific RepoRts | 6:25654 | DOI: 10.1038/srep25654.

16Li, H., Shen, Y., Wu, M., Hou, J., Jiao, C., Li, Z., Liu, X., Bao, X. 2016. Engineering a wild-type diploid Saccharomyces cerevisiae strain for second-generation bioethanol production. Bioresources and Bioprocessing, 3(1), 51.

17Hou J, Jiao C, Peng B, Shen Y, Bao X,” Mutation of a regulator Ask10 pimproves xylose isomerase activity through up-regulation of molecular chaperones in Saccharomyces cerevisiae” Metabolic Engineering, 2016, (38):241-250

18Jin Hou, Yu Shen, Chunlei Jiao, Xingjing Zhang, Xiaoming Bao*, Characterization and evolution of xylose isomerase screened from the bovine rumen metagenome in Saccharomyces cerevisiae. J Biosci Bioeng. 2016, Jul 6, 121(2): 160-165.

19C. Wang#, X. Bao#, Y. Li, C. Jiao, J. Hou, Q. Zhang, W. Zhang, W. Liu, Y. Shen, Cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization, Metab. Eng. 30 (2015) 79–88.

20Wang, C #., Bao, X #., Li, Y., Jiao, C., Hou, J., Zhang, Q., Zhang, W., Liu, W., Shen, Y. *  Data set for cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization. Data Brief, 2015. 4, 119-26. 

21Tang H#, Bao X#, Shen Y, Song M, Wang S, Wang C, Hou J: Engineering protein folding and translocation improves heterologous protein secretion in Saccharomyces cerevisiae. Biotechnology and Bioengineering, 2015, 112(9):1872-82

22Fang, Z., Liu, X., Chen, L., Shen, Y., Zhang, X., Fang, W., Wang, X., Bao, X*., Xiao, Y*. Identification of a laccase Glac15 from Ganoderma lucidum 77002 and its application in bioethanol production. Biotechnol Biofuels, 20158: 54.

23Li, H., Wu, M., Xu, L., Hou, J., Guo, T., Bao, X., Shen, Y*. Evaluation of industrial Saccharomyces cerevisiae strains as the chassis cell for second-generation bioethanol production. Microbial Biotechnology2015 8(2), 266-74.

24Fu, J., Hou, J., Chen, L., Wang, M., Shen, Y., Zhang, Z., Bao, X*. , The Yeast BDF1 Regulates Endocytosis via LSP1 Under Salt Stress. Curr Microbiol. 2015 May; 70(5):671-8. 

专著:

1、《木质纤维素降解酶与生物炼制》,化学工业出版社,2011.7,曲音波 主编,ISBN 978-7-122-11311-5。编著人员(按姓名汉语拼音排序):鲍晓明,陈冠军,方诩,高培基,刘巍峰,曲音波,沈煜,汪天虹,王禄山,赵建。16开,447千字,20119月第1版第1次印刷

2、《生物燃料》,化学工业出版社,2009.10,曲音波 ,鲍晓明 等 译,ISBN 978-7-122-06448-6,16开,360千字,20099月第1版第1次印刷

3、《微生物分子育种原理与技术》,化学工业出版社,汪天虹,鲍晓明等编,ISBN7-5025-7301-116开,20058月第1版第1次印刷

4、《分子生物学实验》,北京大学出版社,汪天虹,鲍晓明等编,ISBN 978-7-301-14436-716开,20094月第1版第1次印刷

5、高东,金建铃,鲍晓明,微生物遗传学,1996,山东大学出版社

专利

侯进,沈煜,鲍晓明,汤红婷:一株持续高效分泌β-葡萄糖苷酶的重组酿酒酵母重组菌株及其应用,ZL201310187648.X 

社会兼职:

  中国微生物学会普及教育工作委员会委员,山东省遗传学会理事,山东省分子与生化学会理事。